Changes of valuable monitors in heparin therapy in glomerular nephropathy
- VernacularTitle:肾小球疾病患者静脉注射肝素后相关监测指标的变化
- Author:
Xuefeng SUN
;
Xijing ZHOU
;
Lining WANG
- Publication Type:Journal Article
- Keywords:
Glomerular nephropathy Heparin Monitors
- From:
Chinese Journal of Practical Internal Medicine
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen out useful monitors of heparin therapy in glomerular diseases.Methods In 40 diabetic nephropathy (DN) patients and 39 chronic glomerulonephritis (CGN) patients,we implemented a bolus venous injection of heparin 1500 U,and measured the parameters of coagulation and fibrinolysis by ELISA at basis and 30 minutes,2 hours after injection.Result After injection with heparin,the levels of prothrombin fragment 1+2 (PF1+2),thrombi-antithrombin Ⅲ (TAT),fibrinopeptide A (FPA) and coagulative factor X (FX) activity significantly decreased,but the activated partial thromboplastin time (APTT) and the other parameters of coagulation-fibrinolysis didn't change in either the DN patients or the CGN patients.Conclusion The level of PF1+2,TAT,FPA and XF activity are valuable monitors in heparin therapy.
