Expressions of MMP-2, MMP-7 and TIMP-2 in lung carcinoma and their significance
- VernacularTitle:肺癌患者肺组织MMP-2、MMP-7和TIMP-2表达及意义
- Author:
Tonghua MEI
;
Bin LUO
;
Yin MA
- Publication Type:Journal Article
- Keywords:
lung neoplasm;
matrix metalloproteinase;
tissue inhibitor of metalloproteinase
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of matrix metalloproteinase 2 (MMP 2), matrix metalloproteinase 7 (MMP 7), and tissue inhibitor of matalloproteinase 2 (TIMP 2) in lung carcinoma tissue and their significance Methods The expressions of MMP 2, MMP 7, and TIMP 2 in 74 cases of lung carcinoma tissues and 20 cases of peri cancerous normal lung tissues were detected by immunohistochemical method, and the correlation between the expressions of these proteins and the clinicopathological parameters and the prognosis was analyzed Results MMP 2 and MMP 7 expressions in lung carcinoma tissues were significantly higher than those in peri cancerous normal lung tissues ( P 0 05), and the expression of TIMP 2 was significantly lower in lung carcinomas with lymph node metastasis than that in lung carcinomas without lymph node metastasis ( P
