Protective effect of rosiglitazone on rat kidney after unilateral ureteral obstruction
- VernacularTitle:罗格列酮对单侧输尿管梗阻大鼠肾脏的保护作用
- Author:
Zhangsuo LIU
;
Genyang CHENG
;
Jie SONG
;
Junhui LI
- Publication Type:Journal Article
- Keywords:
Obstructive nephropathy;
Peroxisome proliferator activated recept or gamma;
Rosiglitazone
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rosiglitazone on the expr es sion of PPAR?,TGF-a1 and PCNA and its mechanism on renal interstitial fibrosi s following unilateral ureteral obstruction(UUO) in rat kidney. Methods Thirty r ats were randomly assigned to shame operation group(sham group),UUO group, rosig litazone(5 mg穔g-1?d-1) treatment group after UUO. Immunohistochemistry,RT-PCR,Western blotting were performed to investigate renal pathological changes an d examine the expression of PPAR?,TGF-a1,PCNA on the 7th and 14th day in the kidney. Results In comparison with the shame group,the expression of PPAR?,TGF-a1,PCNA of UUO and treatment groups increased significantly(P
