Effects of valsartan and benazepril on glomerulosclerosis in rats with 5/6 nephrectomy
- VernacularTitle:缬沙坦及苯那普利对5/6肾切除大鼠肾小球硬化的影响
- Author:
Licai YANG
;
Daoyou ZHANG
;
Hui ZHANG
;
Guilan ZHU
;
Chaoqing GAO
- Publication Type:Journal Article
- Keywords:
angiotensin converting enzyme;
angiotensin receptor antagonist;
glomerlosclerosis;
transforming growth factor? 1;
extracellular matrix
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe and compare the improvement of glomerul- osclerosis in rats with 5/6 nephrectomy by valsartan and benazepril. METHODS: Thirty Sprague-Dawley male rats were selected and performed five-sixths nephrectomy to produce chronic renal failure model. Two weeks after the surgery, the rats were randomly divided into model group, valsartan group and benazepril group, and established a shame group serving as normal control. The weight, blood pressure, blood uria nitrogen (BUN) and serum creatinine were measured on the sixth week after operation, then the rats were killed to take the kidneys for pathological histological observation. Immunohistochemistry was used to examine the expression of TGF-? 1 protein and fibronectin (FN) and collagen IV in glomeruli. RESULTS: As compared with model group, systolic pressure decreased (P
