Study of pharmacological effects and mechanism of ethyl ferulate
- VernacularTitle:阿魏酸乙酯的药理活性及其机制研究
- Author:
Rutao WANG
;
Siyuan ZHOU
;
Feng ZHANG
;
Qibing MEI
- Publication Type:Journal Article
- Keywords:
ethyl ferulate;
blood platelets;
calcium ion;
acute liver injury;
MDA
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the pharmacological effects and mechanism of ethyl ferulate (EF). METHODS: The platelet congregate rate was observed by congregater TYXN-91 and the platelet intracellular calcium oscillation was observed by laser scanning. The acute liver injury model of mice was made by using the CCl 4 156 mg?kg -1, ip. Then the levels of ALT and AST were determined in serum and the levels of MDA and SOD in the liver. RESULTS: The inhibition rate of the platelet congregate were 26.3%? 3.3%, 33.4%? 2.4%, 73.4%? 3.1%, and 94.9%? 2.7% (n=8) in different concentration( 0.1, 0.5, 1.5, and 3.0 mmol?L -1)of ethyl ferulate,respectively. It was higher than those in the same concentrations of ferulic acid. The change of the fluctuation of calcium (?FI 4.6? 1.7) in EF group was much lower than the rest level ( 10.3? 2.6) (n=8,P
