Blocking C-KIT leading disturbance of basic electrical rhythms and loss of interstitial cells of Cajal in murine small intestine
- VernacularTitle:阻断C-KIT导致小鼠小肠基本电节律紊乱及Cajal间质细胞缺失
- Author:
Houjun JIA
- Publication Type:Journal Article
- Keywords:
basic electrical rhythms;
interstitial cells of Cajal;
C-KIT;
small intestine
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the basic electrical rhythms in vivo and distribution of interstitial cells of Cajal(ICC),and the effect of blockade of C-KIT on them in the Balb/c murine small intestine.Methods New-born murine were intraperitoneally with injected antibody to C-KIT(ACK_(2))(100 ?g) every second day,and control groups were injected saline.The basic electrical rhythms in vivo were determined and the distribution of ICC was observed by immunohistochemistry when the murine were 10 days postpartum.Results The basic electrical rhythms in vivo were proximal cosinal waves in control groups and irregular in ACK_(2) groups.The frequency and the amplitude in ACK_(2) groups were significantly lower than that in control groups(P
