Expression of type Ⅰ transforming growth factor ? receptor in renal cortex of streptozotocin-induced type Ⅱ diabetic rats and the regulation of valsartan
- VernacularTitle:TGF?_1型受体在2型糖尿病大鼠肾皮质的表达及缬沙坦调节作用
- Author:
Min ZHENG
;
Min HE
;
Jiliang XU
;
Xiaoqin YIN
- Publication Type:Journal Article
- Keywords:
type Ⅱ diabetic nephropathy;
valsartan;
transforming growth factor beta;
rat
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression of type Ⅰtransforming growth factor ?(T?R-Ⅰ)in renal cortex in streptozotocin-induced type Ⅱ diabetic mellitus and the regulation of valsartan. METHODS: The rat models of type Ⅱ diabetic rats were made. At the end of the 20th weeks,the kidneys were taken out to measure the expression of T?R-ⅠmRNA by RT-PCR. RESULTS: The expression of T?R-ⅠmRNA in diabetic rats without any therapy ( 0.72? 0.14) was higher than that in control ( 0.26? 0.12) (P
