The effect of partial liquid ventilation on pulmonary tissue in rabbits with pulmonary edema following seawater drowning
- VernacularTitle:部分液体通气对兔海水淹溺型肺水肿的气体交换和病理组织学的影响
- Author:
Xinhong ZHANG
;
Yunyou DUAN
- Publication Type:Journal Article
- Keywords:
partial liquid ventilation;
perfluorocarbon;
seawater drowning;
pulmonary edema;
rabbits
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of partial liquid ventilation (PLV) and conventional mechanical ventilation(CMV) on gas exchange in lung injury due to pulmonary edema as a result of seawater drowning in rabbit. Methods Twenty-four healthy male new Zealand rabbits were randomly divided into three groups ( n =8). Pulmonary edema was produced in all rabbits by drowning in sea water. Rabbits of PE group received no treatment,that of CMV group were treated with conventional mechanical ventilation and PEEP,and that of PLV group with CMV,combined with PEEP and FDC. All rabbits were treated for 3 hours. Blood gases,TNF-?in plasma and pulmonary histopathology were determined during the experiment. Results In PLV group,PaO_2 was increased obviously,inflammatory exudate was reduced,and alveolar and interstitial edema was alleviated. The plasma level of TNF-?was significantly lower in PLA group compared with PE group,( P
