Clinical study of anti-oxidant effects of vitamin E-modified membrane on hemodialysis patients
- VernacularTitle:维生素E修饰的透析膜抗氧化作用临床研究
- Author:
Yiwen ZHAO
;
Zhigang WANG
- Publication Type:Journal Article
- Keywords:
Hemodialysis Oxidative Stress Vitamin E-modified membrane
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the anti-oxidant effects of vitamin E -modified membrane in hemodialysis patients.Methods In our four-week study,57 patients on maintenance hemodialysis were divided randomly into three groups.Group A (n=19) resorted to hemodialysis with VitE-modified membrane;Group B (n=19) resorted to hemodialysis with conventional dialyzers and oral VitE intake(400mg/d);Group C (n=19) resorted to hemodialysis with neither vitamin E-modified membrane nor vitamin E intake.Blood samples were collected prior to the first and thirteenth dialysis sessions,and were employed to determine the concentrations of malonylaldehyde (MDA),glutathione peroxidease (GSH-px),glutathione (GSH),superoxide dismutase (SOD) and Vitamin E in plasma and red blood cells (RBC),and advanced oxidative protein products (AOPP) in plasma.Results In group A,there were significant increase in VitE,GSH-px,GSH and SOD levels,and declined MDA and AOPP levels in plasma and in RBC(P0.05).Conclusion Our study suggests that VitE may have anti-oxidant effects on hemodialysis patients,and that VitE-modified membrane may have more advantages in anti-oxidative effect compared with.VitE oral administration.
