Curative effects of fluvastatin in early diabetic nephropathy
- VernacularTitle:氟伐他汀治疗早期糖尿病肾病疗效分析
- Author:
Henglian WU
;
Hongchu LIN
;
Yueying CHEN
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy Fluvastatin C-reactive protein Microalbuminuria Urinary albumin excretion rate
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effects of fluvastatin and its anti-inflammation mechanism in early diabetic nephropathy (EDN).Methods 140 patients with EDN were randomly divided into two groups,the control group (n=70) and the treated group (n=70).The control group received conventional therapy,while the treated group was added oral 40 microgram of fluvastatin every night.Compare the UAER,Scr and CRP 3,6 and 9 months later respectively.Results UAER and Scr had been decreased more significantly and quickly(three months earlier) in treated group than in control group. CRP had been decreased significantly in treated group,while no significant decrease had been found in control group during the follow-up of nine months.Furthermore,similar results were also obtained in those EDN with normolipidemia when further analyzed.Conclusion Fluvastatin can ameliorate microalbuminuria and improve renal function by its anti-inflammation effect by decreasing CRP,which is independent of its lowering lipidemia effect.
