Research progress in opioids induced oxidative injury
- VernacularTitle:阿片类药物诱导机体氧化性损伤的研究进展
- Author:
Fan YANG
;
Jiankai LIU
- Publication Type:Journal Article
- Keywords:
opioids;
oxidative injury;
GSH;
ROS;
xanthine oxidase
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Opioids were widely applied to analgesia and treatment of coughing, diarrhea, anxiety and sleepless. Opioids had toxic effects while playing pharmaceutical roles with oxidative injury as one of the most important toxic effects. Multi-organ or systems in our body were more liable to be damaged either by opioids reduced concentration of glutathione, the reductant or antioxidant, or by increased concentration of reactive oxidative species. To further clarify the research progress in opioids induced oxidative injury is very important towards opioids applications as well as prevention and cure of drug abuse.
