Effects of pioglitazone on hypertrophic myocardial cells induced with high glucose and high insulin
- VernacularTitle:吡格列酮对高糖高胰岛素诱导的心肌细胞肥大的影响
- Author:
Qingfeng ZHOU
;
Hongxin WANG
;
Yiwei WANG
;
Dan SHAN
;
Lijuan FU
- Publication Type:Journal Article
- Keywords:
pioglitazone;
high glucose;
high insulin;
hypertrophic myocardial cells
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of pioglitazone on the hypertrophic myocardial cells induced with high glucose and high insulin. Methods Using cultured myocardial cells as a model, The protein content was assayed with Lowrys method; The contracting frequency was counted by the inverted microscope;The protein synthesis was assayed with leucine intake method;The cardiomyocytes volumes was measured by computer photograph analysis system; the cellular hypertrophy was observed. Results Compared with verapamil, Pioglitazone significantly inhibited the protein content, cellular protein synthesis and volumes of cultured hypertrophic myocardial cells induced with high glucose and high insulin. Meanwhile pioglitazone and verapamil inhibited myocardial cells contracting frequency too. Conclusions Pioglitazone inhibited cardiac hypertrophy of cultured myocardial cells induced with high glucose and high glucose. The mechanism of the effect of pioglitazone on cardiac hypertrophy needs further study.
