ENGLISH ABSTRACTS OF ORIGINAL ARTICLES——Effect of Transfusion with Stored Blood after Combined Radiation-Burn Injury on Immune Reaction of Allo-Skin Grafted Rats
- VernacularTitle:放烧复合伤后输贮存血对异体植皮大鼠免疫反应的影响
- Author:
Yongtang YAN
- Publication Type:Journal Article
- Keywords:
Combined radiation-burn injury;
Transfusion with stored blood;
Allo-skin graftment;
Immune reaction
- From:
Chinese Journal of Blood Transfusion
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of post-injury transfusion with stored blood on the immune reactionof allo-skin grafted rats was treated,using models of the allo-skin grafted ratswith simple burn injury (15% TBSA) and with combined radiation-burn injury(exposed to 5 Gy systemic irradiation,15% TBSA) respectively.After burninjury and allo-skin graftment,the early cell immune function of the rats signifi-cantly enhanced,the survival time of all the allo-skin grafts was within 7 days.After the rats transfused with stored blood,the degree of their cell immunefunction enhancement was decreased,but there was no significant effect on thesurvival time of allo-skin grafts.However,in the case of allo-skin graftmentsubsequent to combined radiation-burn injury,and then transfusion with storedblood,the multiplying ability of thymocytes and the antibody-producing abilityof splenocytes were depressed significantly and for a long time;the number ofthymocytes,splenocytes,spleen B-cells,T-cells,T_H-cells and Ts-eells were decr-eased rapidly and recovered slowly.And the surviral rate of allo-skin grafts for15 days was 100.0% which was remarkably higher than that of the group subject-ed to simple allo-skin graftment (28.6%,P
