The synthesis and metabolism of neurosteroids and the effects on the nervous system
- VernacularTitle:神经甾体的合成和代谢及其对神经系统作用
- Author:
Dan WANG
;
Yingqing LU
;
Rong YU
- Publication Type:Journal Article
- Keywords:
neurosteroids;
pregnenolone;
progesterone;
allopregnanolone;
dehydroepiandrosterone;
nervous system
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Neurosteroids exist in central and peripheral nervous system, independence of peripheral glands, including pregnenolone, progesterone, allopregnanolone, and dehydroepiandrosterone, etc. They can be synthesized in the nervous system from sterol or sterol precursors catalyzed by certain enzymes. They play roles by interacting with GABAA, NMDA or?receptors, and have effects on memory, sleep, convulsion, cellular excitability, etc.
