Relation between modulation of the N-methyl-D-aspartate receptor and cyanide-induced neurotoxicity
- VernacularTitle:N-甲基-D-天冬氨酸型谷氨酸受体的调节与氰化物中枢毒作用
- Author:
Bola WU
;
Tongjun ZHU
- Publication Type:Journal Article
- Keywords:
N-methyl-D-aspartate (NMDA) receptor;
neuronal excitotoxicity;
cyanide neurotoxicity;
glutamate (Glu)
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Cyanide can activate the N-methyl-D-aspartate (NMDA) receptor by two approaches directly and indirectly. Firstly cyanide-induced depletion of energy is associated with the activation of NMDA receptors indirectly by increasing extracellular glutamate (Glu) and affecting cytosolic Ca 2+ homeostatic mechanisms. Secondly most likely as a conditioner of the NMDA receptor, cyanide enhances NMDA receptors responses by modulating redox sites of cysteine residue located in the subunit NR 1 or NR 2 of the NMDA receptor. NMDA receptor-induced neurotoxicity, initiated by the direct or indirect activation of NMDA receptor, leads to neuronal injury, apoptosis or necrosis finally. Therefore, it is believed that the activation of the NMDA receptor is presumably the key event in the mechanism of cyanide-induced neuronal injures.
