Research on relationship between interleukin-1 receptor antagonist and airway hyperresponsiveness
- VernacularTitle:白细胞介素-1受体拮抗剂与气道高反应性关系的研究
- Author:
Xueqin CHEN
;
Xia ZAO
;
Jiong YANG
;
Zuoyan CAO
- Publication Type:Journal Article
- Keywords:
interleukin-1ra;
asthma;
airway hyperresponsiveness;
neutrophils
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the relationship between interleukin-1receptor antagonist (IL-1ra) and airway hyperresponsiveness (AHR) of asthma. METHODS: The airway responsiveness to inhaled histamine as PC 20 was evaluated among the normal guinea pigs, and sensitized with ovalbumine (OA) and challenged 14 days later (athma group), and injected IL-lra 1 mg?kg -1 intravenously 30 minutes before challenged (asthma plus IL-lra group). The numbers of different cells was counted and classified in bronchoalveolar lavage fluid (BALF). RESULTS: The PC 20 of the asthma plus IL-1ra group was higher than that of asthma group (P
