A method for improving acute cumulative death rates in animals by intravenous administration
- VernacularTitle:应用计算机模拟推演动物急性累计死亡率法
- Author:
Chengyu LU
;
Haiyan WANG
;
Tie WU
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
pharmacokinetics;
acute cumulative death rates;
computer simulator
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To improve on the acute cumulative death rates method in animal by intravenous (iv) administration. METHODS: A mathematic model was established to simulate the pharmacodynamic and pharmacokinetic process by the program written by Visual Basic.net. This program evaluated the acute cumulative death rates (ACD method) for use of pharmacokinetics of traditional Chinese medicine (TCM). RESULTS: The ACD method related on its first dosage, and an unsuitable dosage could lead to a wrong results. It also had been proved that, by adjusting the 2nd dosage it was a more suitable to wider range of dosage. CONCLUSION: By suitable 2nd dosage and enough animal number, ACD method can be used in the pharmacokinetics of TCM.
