Application of optical coherence tomography technique in the research of rat retinal light damage
- VernacularTitle:光学相干断层扫描在大鼠视网膜光损伤研究中的应用
- Author:
Shuxing JI
;
Mi YAN
;
Junjun ZHANG
- Publication Type:Journal Article
- Keywords:
optical coherence tomography;
light damage;
retinal degeneration
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of optical coherence tomography (OCT) in the rat retinal light damage. Methods Albino Sprague-Dawley (SD) rats (5-8 weeks of age) were exposed to 1 000-1 400 lux of diffuse, cool, white, fluorescent light for 2, 5, and 7 d. OCT image analysis and histological measurements of the retinal thickness were performed. Animals were then sacrificed and the measured results were compared with those by histological examination. Results The sensory retinal thickness of the retina in the rats thinned progressively as the retinal degeneration was in progress. The sensory retinal thickness measured by OCT [the corresponding thickness was (179.11?12.01)?m, (159.27?12.81)?m, and (133.67?11.43)?m, respectively] was well correlated with that measured by histology [the sensory retinal thickness after exposure to the light for 2, 5, and 7 d was (144.26?9.36)?m, (116.16?11.24)?m, and (94.27?10.68)?m, respectively] (r= 0.995, P
