TH1/TH2 patterns in the peripheral blood of pregnancy-induced hypertension patients
- VernacularTitle:妊娠高血压综合征患者外周血TH1/TH2模式
- Author:
Jingping ZHU
;
Yunhe GAO
;
Min LI
- Publication Type:Journal Article
- Keywords:
pregnancy-induced hypertension;
TH1 cell;
TH2 cell
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the TH1/TH2 patterns by calculating the percentage of TH1, TH2 cells, and the TH1/TH2 ratio of peripheral blood from patients with pregnancy-induced hypertension (PIH). Methods The percentage of TH1 and TH2 cells in peripheral blood from 15 normal pregnant controls and 20 PIH patients (including 12 moderate and 8 severe cases) were calculated using flow cytometry for the analysis of both the surface marker CD3 CD8 and intracellular cytokines, interleukin-4 (IL-4), and interferon-? (IFN-?). Results The percentage of TH1 cells and the ratio of TH1/TH2 in PIH patients were significantly higher than those in the normal third-trimester pregnant controls [(20.50?4.02)% vs (12.57?2.18)%, P
