Effects of FFBJRGP on collagen deposition in hepatic Disse space in alcohol induced liver fibrosis in rat
- VernacularTitle:复方鳖甲软肝片对酒精性肝纤维化狄氏间隙胶原沉积的影响
- Author:
Jian LI
;
Jianzhao NIU
;
Yan ZENG
- Publication Type:Journal Article
- Keywords:
liver cirrhosis, alcoholic;
collagen;
fufangbiejiaruanganpian
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Fufangbiejiaruanganpian (FFBJRGP) on deposition of collagens around hepatic Disse space in experimental alcohol liver fibrosis (ALF). Methods The ALF rat model was induced by feeding a mixture of alcoholic liquid which included alcohol, vegetable oil and pyrazole, combined with a high fatty food. Then, all of the ALF rats were treated with FFBJRGP in high, moderate, and low dose. At the time of termination of the treatment, HYP level in liver tissue, collagen Ⅳ and LN levels in the serum and pathological changes were studied by Mallory stain and sirius red stain. Results The levels of HYP in hepatic tissues, collagen Ⅳ and LN in sera are increased remarkably in ALF rats, while all these indexes were reduced after moderate or low-dose FFBJRGP treatment (P
