A comparison of effect of single versus double daily dose of human granulocyte colony-stimulating factor on mobilization of peripheral hematopoietic stem cells in healthy donors
- VernacularTitle:单次和分次应用G-CSF动员供体外周血造血干细胞的效果比较
- Author:
Xiubin XIAO
;
Mei GUO
;
Jianhui QIAO
- Publication Type:Journal Article
- Keywords:
granulocyte colony stimulating factor;
stem cell mobilization;
donor
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the results of mobilization of peripheral stem cells of two different G-CSF dosage schedules in 30 healthy donors. Methods In one group 15 healthy subjects received 5?g/kg filgrastim once daily subcutaneously (SC), while in the other group another 15 individuals received 2.5?g/kg of filgrastim twice daily SC. Peripheral blood stem cells were collected after five days of filgrastim administration, and flow cytometric immunophenotyping was performed for the first harvest. Results The MNC count was 2.93?10 8/kg donor body weight in the 5?g/kg Qd group compared with 4.42?10 8/kg in the 2.5?g/kg bid group (P0.05). Conclusion Administration of filgrastim twice a day at 2.5?g/kg instead of once a day at 5?g/kg is more efficient in mobilizing stem cells without obvious side effect.
