Significance of VEGF and Cath-D expressions in tissue arrays of patients with recurrent laryngeal carcinoma
- VernacularTitle:VEGF、Cath-D在喉复发癌组织芯片中的表达和意义
- Author:
Rui GUO
;
Deliang HUANG
;
Jiafu JI
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
recurrence;
tissue arrays
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis of recurrent laryngeal cancer after surgieat treatment, the study was designed to investigate the relationship of VEGF and Cath-D expression in patients with recurrent laryngeal carcinoma. Methods Five hundred and seventy-four cases of laryngeal carcinoma treated in our department from 1958 to 1999 were retrospectively reviewed. All patients were observed for 3 years postoperatively. The whole set of tissue microarrays prepared with tumor tissue from 574 patients, including recurrent tumor tissue from 56 patients, and also 39 normal laryngeal tissue from normal subjects. The tissue chips were analyzed by the SABC immunohistochemical method. Results VEGF and Cath-D were expressed in most of the laryngeal carcinoma and normal laryngeal tissue, but the positive ratio of them was different. There was higher expression of VEGF and Cath-D in recurrent laryngeal carcinoma compared with that in laryngeal carcinoma without recurrence and normal laryngeal tissue (P
