Protective effect of hyperoxic solution on phosgene-induced lung injury
- VernacularTitle:高氧液体对兔窒息性中毒肺水肿指标的影响
- Author:
Ling WANG
;
Wei CHAI
;
Lixian XU
- Publication Type:Journal Article
- Keywords:
phosgene;
hyperoxic solution;
lung injury;
malonyldialdehyde;
broncho-alveolar lavage fluid
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of a hyperoxic solution on phosgene-induced lung injury by observing the changes in W/D ratio, lung water (LW), and L/B, and MDA contents, GSH-PX activity, and protein contents in broncho-alveolar lavage fluid (BALF). Methods The rabbits were divided into normal control group, hyperoxic solution (HO) and balance salt(BS) groups.Group HO and Group BS inhaled phosgene, and hyperoxic solution was given intravenously in group HO, but BS was given in group BS. W/D, LW, L/B, and MDA contents,GSH-PX activity,protein contents in broncho-alveolar lavage fluid (BALF) were determined. Results The MDA contents, W/D, LW and L/B were increased, and GSH-PX activity was decreased significantly in Group HO and Group BS compared with control group (P
