Effects of simvastatin on expression of vascular endothelial growth factor in human umbilical vein endothe lial cells
- VernacularTitle:辛伐他汀对人脐静脉内皮细胞血管内皮生长因子表达影响的初步研究
- Author:
Lu ZHANG
;
Zonggui WU
;
Yuecheng HUANG
;
Ping YANG
;
Lin HAN
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
atherosclerosis;
human umbilical vein endothelial cells;
simvastatin
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of simvastatin on the expression of vascular endothelial growth factor (VEGF)and its receptor in cultured human umbilical vein endothelial cells(HUVEC).Methods:Cells were randomly divided into simvastatin group,tumor necrosis factor-?(TNF-?)group,simvastatin+TNF-?group,interleukin-1?(IL-1?)group,simvastatin+IL-1?group and control group.The effects of TNF-?,IL-1?and simvastatin on the protein levels of VEGF and its receptor in HUVEC were studied by immunocytochemistry.Results:The protein levels of VEGF and its receptor in TNF- ?group and IL-1?group were significantly higher than those of control group,and simvastatin decreased the protein levels of VEGF and its receptor in TNF-?group and IL-1?group.Conclusion:Simvastatin can decrease the protein levels of VEGF and its receptor in HUVEC. [
