Changes of angiotensin1at different stages of atherosclerosis in rats
- VernacularTitle:大鼠动脉粥样硬化不同阶段的血管紧张素变化
- Author:
Yansong GUO
;
Zonggui WU
;
Junke YANG
;
Gaozhong HUANG
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
high lipid;
vitamin D;
endothelium injury;
angiotensinⅡ
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relation between the angiotensinⅡ(AngⅡ)levels in thoracic aorta and plasma and atherosclerosis(AS).Methods:Totally40healthy male Wistar rats were randomly divided into4groups(n=10).Four different feeding methods,including normal diet,high lipid,high lipid+vitamin D overload,and high lipid+vitamin D over-load+endothelium injury,were used for inducing AS in rats.The thickness of intima was taken as the index of AS severity, radio-immunity analysis was used to assay AngⅡin each group in thoracic aorta and plasma.Results:Only rats in high lipid diet group did not develop AS plaque;high lipid+vitamin D only resulted in AS fibrous plaque with VSMC proliferation;high lipid+vitamin D+endothelium injury formed ripe AS plaque.The thickness of intima and AngⅡof thoracic aorta in-creased gradually compared with control group(P
