Recent progress and propect in the studies of pinacidil roles on myocardial protection
- VernacularTitle:吡那地尔对心肌保护作用机制的研究进展
- Author:
Nianyin PENG
;
Hong ZHOU
;
Liangyi SI
- Publication Type:Journal Article
- Keywords:
myocardium;
pinacidil;
mitochondria
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, it was found that heart was significantly protected against ischemia-reperfusion injury if it was first preconditioned by brief ischemia or by administering a potassium channel opener. Both of these preconditioning strategies were found to require opening of a K(ATP) channel, we showed that this pivotal role was mediated by the mitochondrial ATP-sensitive K+ channel (mitoK(ATP)). As the mechanism was not clarified yet, this paper reviewed the evidence showing that the mechanism and the characters of mito K(ATP) and its cardioprotection against ischemia-reperfusion injury
