Caco-2 cell model——an effective tool for the research of drug absorption
- VernacularTitle:Caco-2细胞模型——药物吸收研究的有效“工具”
- Author:
Su GUAN
;
Xiao CHEN
;
Min HUANG
- Publication Type:Journal Article
- Keywords:
Caco-2 cell model;
drug absorption;
absorption mechanism
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The absorption process is an important factor in determining the bioavailability of orally administered drugs. however, the absorption mechanism of many drugs is not clear. Caco-2 cell model is the best in vitro absorption model nowadays. It is widely used in the research on drug absorption process and absorption mechanism, especially in the aspect of traditional Chinese medicine absorption, the use of Caco-2 cell model has become the hot spot recently. Mo- reover, Caco-2 cell model is also applied in the research on drug metabolism. Therefore, Caco-2 cell model will become an important method in the research of drug absorption, and will be helpful to accelerate the process of new drug screening and development.
