Effects of berberine on potassium current of guinea pig colonic smooth muscle cells
- VernacularTitle:黄连素对结肠平滑肌细胞膜钙激活钾通道和延迟整流钾通道的影响
- Author:
Mingkai CHEN
;
Hesheng LUO
;
Baoping YU
- Publication Type:Journal Article
- Keywords:
berberine;
colonic smooth muscle;
patch clamp;
calcium-activated potassium current;
delayed-rectifier potassium channel current
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To clarify the mechanism of berberine on mobility diarrhea by investigating the effects of berberine on calcium-activated potassium current I K(Ca) and delayed-rectifier potassium channel current I K(V) of guinea pig colonic smooth muscle cells. METHODS Single guinea pig colonic smooth muscle cells was isolated by collagenase; The effects of berberine on I K(Ca) and I K(V) were detected by using patch clamp technique, under the conventional whole cell patch clamp mode. RESULTS 10, 50, 100 ?mol?L -1 berberine inhibited I K(Ca) of guinea pig colonic smooth muscle cells significantly (P
