Effect of lovastatin and probucol on intracellular cholesterol content in foam cells derived from mouse peritoneal macrophages
- VernacularTitle:洛伐他汀、普罗布考对小鼠巨噬细胞源性泡沫细胞内胆固醇含量的影响
- Author:
Dong WANG
;
Hua DING
;
Hongyan XU
;
Xinbing WEI
- Publication Type:Journal Article
- Keywords:
macrophage;
atherosclerosis;
lovastatin;
probucol;
cholesterol efflux;
plague regression
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To examine the effects of lovastatin, probucol on the intracellular cholesterol content and cholesterol efflux. METHODS With the model of foam cells through depositing the oxidized low-density lipoprotein (OXLDL) into mouse peritoneal macrophages, intracellular cholesterol content was examined by high performance liquid chromatography after the administration of lovastatin and probucol at different concentration. RESULTS The CE/TC ratios of the model group were beyond 50% and extremely higher than those of the normal and negative groups, suggesting that the model of foam cells was established triumphantly. Lovastatin decreased intracellular TC, CE and CE/TC significantly and dose-dependently. Probucol also possessed such effects on intracellular TC, CE, but no dose-dependently, and no effect on the ratio of CE/TC. CONCLUSION The results showed lovastatin might be conducive to plagues stability by increasing cholesterol efflux from the foam cells and decreasing the intracellular cholesterol content. Probucol did not have this effect although it decreased intracellular TC and CE content.
