Apoptosis induced by thermochemotherapy of adriamycin (ADM) and the change of mitochondial transmembrance potential in A549 cells
- VernacularTitle:阿霉素热化疗诱导A549细胞凋亡及线粒体跨膜电位的变化
- Author:
Jixian ZHANG
;
Qikun ZHANG
;
Yixin WAN
- Publication Type:Journal Article
- Keywords:
adriamycin;
thermochemotherapy;
A549 cells;
motochondial transmembrane potential
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of apoptosis and the change of mitochondial tansmembrane potential in A549 cells induced by thermochemotherapy of ADM. METHODS: ADM of different concentrations was directly applied to A549 cells cultivated in vitro. Cells maintained at 42.5 ℃ for 30 min. RESULTS: The inhibition of A549 cells was increased by thermochemotherapy of ADM significantly,and the cytoplasmic concentration of thermochemotherapy of ADM was significantly higher than that of chemotherapy (P
