Expression of vascular endothelial growth factor in chronic hypoxia and hypercapnia rats and effects of SHENYI Capsule
- VernacularTitle:慢性低O_2高CO_2大鼠血管内皮生长因子表达及参一胶囊的影响
- Author:
Yanfan CHEN
;
Shaoxian CHEN
;
Xiaofang FAN
;
Liangxing WANG
- Publication Type:Journal Article
- Keywords:
hypoxia;
hypercapnia;
pulmonary hypertension;
vascular endothelial growth factor;
SHENYI Capsule
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the roles of vascular endothelial growth factor (VEGF) in hypoxia pulmonary hypertension and effects of SHENYI Capsule. METHODS: Thirty SD rats were randomly divided into normal control group (N), hypoxia hypercapnia group (F), and hypoxia hypercapnia+SHENYI Capsule group (S). The levels of VEGF in serum and lung tissue are measured by ELISA, the ultrastructure of pulmonary arterioles was observed by electron microscopy, and the expression of VEGFmRNA was observed by in situ hybirdization. RESULTS: Mean pulmonary arterial pressure (mPAP), weight ratio of RV to LV+S, the levels of VEGF in serum, and lung tissue of group F were significantly higher than those of group N and group S (P
