Effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis
- VernacularTitle:幽门螺杆菌感染对慢性胃炎胃黏膜细胞增殖的影响
- Author:
Zhengxin LIU
;
Baowen CHEN
;
Guibin YANG
;
Xiquan ZHANG
;
Boq JIA
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Gastric mucosal;
Proliferating cell nuclear antigen;
Epidermal growth factor;
Receptors,transforming growth factor beta
- From:
Journal of Peking University(Health Sciences)
2004;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis. Methods: Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type Ⅰand typeⅡ(TGF?RⅠ, TGF?RⅡ) in gastric mucosa were examined by immunohistochemical method. Results: The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P
