Induction of spondylitis and sacroiliitis in mice by the G1 domain of the proteoglycan versican
- VernacularTitle:蛋白聚糖Versican V1区诱导小鼠脊柱炎和骶髂关节炎模型的建立
- Author:
Jian ZHU
;
Feng HUANG
;
Mianson ZHAO
- Publication Type:Journal Article
- Keywords:
spondylitis, ankylosing;
disease models, animal;
autoimmunity;
proteoglycans, Versican
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To set up rodent ankylosing spondylitis model. Methods Recombinant natively folded versican G1 domain(VG1) and FCA were injected into BALB/c mice to induce spondylitis and sacroiliitis. Spondylitis and sacroiliitis were determined by pathological examination. Results It was shown that immunity to recombinant VG1 resulted in spondylitis in the lumbar spine and sacroiliitis in 35 0% and 12 5% mice respectively. Accumulation of mononuclear cells was observed in spinal ligaments adjacent to the intervertebral disc, the intervertebral disc and the sacroiliac joints. No clinical peripheral arthritis was observed. Conclusion These observations suggest that immunity to human VG1 is involved in the induction of experimental spondylitis and sacroiliitis in BALB/c mice, which will do some help to probe the pathogenesis of human ankylosing spondylitis
