Clinical study on G-CSF application in peripheral blood stem cell transplantation donor with G-CSF.
- VernacularTitle:造血干细胞移植供者应用粒细胞集落刺激因子的研究
- Author:
Zhuogang LIU
;
Huan WANG
;
Baofu SHI
- Publication Type:Journal Article
- Keywords:
Granulocyte colony stimulating factor Peripheral blood stem cell transplantation donor Side effect
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of the cellular composition in peripheral blood stem cell transplantation(PBSCT) donor with granulocyte colony stimulating factor(G-CSF)and the short-term influence of G-CSF on the donors.Methods Eighteen donors of PBSCT were administrated with G-CSF,5-10?g/(kg?d),for 4-5d.Peripheral blood mononuclear cells (MNC) were collected after the administration of the G-CSF and analyzed by flow cytometry.The side effects of G-CSF on donors were also studied.Results The peripheral white blood cell (PWBC) counts peaked on day 4 or 5 after mobilization.Compared with the number of WBC before mobilization,it increased 7 to 14 times after mobilization (P
