Effects of intrathecal administration of strychnine on propofol induced antinociception
- VernacularTitle:鞘内注射士的宁对丙泊酚镇痛作用的影响
- Author:
Jie YU
;
Tijun DAI
;
Shiming DUAN
;
Yinming ZENG
- Publication Type:Journal Article
- Keywords:
propofol;
strychinine;
receptor, glycine;
spinal cord;
antinociception
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05),but the HPPT was dose-dependently increased in 25 and 50 mg?kg -1 groups(P0.05); on the contrary ,strychnine 0.5,0.75,1.0 ?g(it) decreased the HPPT of propofol-treated mice as doses increased(P0.05). CONCLUSION Propofol can induce antinociception in hot-plate test and acetic acid-induced writhing test of mice. Spinal glycine receptors may play a role in propofol's antinociceptive properties in hot-plate test of mice.
