Effects of iptakalim hydrochloride on cerebral neuronal sodium, calcium and potassium channels
- VernacularTitle:盐酸埃他卡林对脑神经元钠、钾、钙通道的影响
- Author:
Yingli ZHANG
;
Wenyu CUI
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
iptakalim hydrochloride;
hippocampus;
neuron;
ion channel;
patch-clamp technique
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of iptakalim hydrochloride (Ipt) on cerebral neuronal sodium, calcium and potassium channels. METHODS The effects of Ipt on sodium, calcium and potassium channels in cultured hippocampal neurons was observed using whole-cell recording technique. RESULTS Ipt had no significant effect on Na +, Ca 2+ currents, but significantly increased the outward K + currents. This enhancement of Ipt was inhibited by synchronously application of glibenclamide. Upon the administration of Ipt 1, 10, 100 ?mol?L -1, the outward K + current was significantly increased to (121.9?8.1)%, (114.7?7.1)%, (109.1?10.0)% respectively (n=6～9, P
