Apoptosis of macrophage induced by E_2 at high concentration
- VernacularTitle:高浓度17?-雌二醇诱导巨噬细胞凋亡
- Author:
Min HONG
;
Xiaoyu SUN
;
Xiaodong LI
;
Quan ZHU
- Publication Type:Journal Article
- Keywords:
estradiol;
macrophage;
intracellular Ca 2+;
matochontrial transmembrane potential
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of 17?-estradiol(E 2) on apoptosis of macrophages at certain concentration.METHODS Fluorescent microscopy and scanning eletron microscopy(ESEM) were used to detect apoptosis changes of macrophages induced by E 2 at relatively high concentration and intracellular Ca 2+ and matochontrial transmembrane potential were examined by laser scanning confocal microscopy(LSCM). RESULTS Apoptosis of macrophages was induced by high concentration of E 2 (≥1 ?mol?L -1). Intracellular Ca 2+ elevated and matochontrial transmembrane potential decreased after E 2 treatment. CONCLUSION Apoptosis of macrophages is induced by certain concentration of E 2 (≥1 ?mol?L -1) and this may be related to elevated intracellular Ca 2+ and decreased matochontrial transmembrane potential.
