The Postoperative Antiemetic Effect of Midazolam in Patients Undergoing Appendectomy.
10.4097/kjae.1999.37.6.1095
- Author:
Sang Yoon CHO
1
;
Mi Kyung OH
;
Jong Hoon YEOM
;
Woo Jong SHIN
;
Yong Chul KIM
;
Dong Ho LEE
Author Information
1. Department of Anesthesiology, Hanyang University College of Medicine, Suwon, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthetics, intravenous, propofol;
Antiemetics, midazolam;
Complication, vomiting;
Surgery, appendectomy
- MeSH:
Anesthesia;
Antiemetics*;
Appendectomy*;
Emergencies;
Humans;
Incidence;
Midazolam*;
Nitrous Oxide;
Oxygen;
Postoperative Nausea and Vomiting;
Propofol;
Recovery Room;
Vomiting
- From:Korean Journal of Anesthesiology
1999;37(6):1095-1100
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Postoperative nausea and vomiting are common postoperative complaints. The purpose of this study was to assess the effect of preoperative midazolam on vomiting after appendectomy. METHODS: Sixty patients, aged 10 64 yr, undergoing emergency appendectomy were randomly allocated to receive midazolam 30, 50, 75 microgram/kg or placebo after induction of anesthesia. Anesthesia consisted of 67% nitrous oxide, 33% oxygen and propofol infusion 6 10 mg/kg/h. Postoperative vomiting was checked by the recovery room nurse at 1 h after operation and we examined the incidence of postoperative vomiting at 24 h after operation. RESULTS: Midazolam reduced the overall incidence of vomiting, especially in the midazolam 50 and 75 microgram/kg groups, completely abolishing vomiting (P< 0.05). However, in the midazolam 75 microgram/kg group, there was a delay in eye opening time (P< 0.05). CONCLUSIONS: Preoperative injections of midazolam 30 or 50 microgram/kg were useful to prevent postoperative vomiting in patients undergoing appendectomy without delayed recovery.
