Effects of xanthotoxol on physiological characteristics of isolated guinea pig atrium
- VernacularTitle:花椒毒酚对豚鼠离体心房肌生理特性的影响
- Author:
Jianxing LIU
;
Qing ZHOU
;
Li ZHOU
;
Qishen LIAN
- Publication Type:Journal Article
- Keywords:
xanthotoxol;
coumarin;
guinea pig auricle;
functional refractory period;
contractility
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of xanthotoxol (XT) on physiological characteristics and its mechanism in isolated guinea pig atria. METHODS: It was determined by the contractile amplitude,excitability and the spontaneous beats in the right atria,respectively. RESULTS: In the experiment of contractile amplitude,after 15 min of administration of XT 20, 40 and 80 ?mol?L -1 ,the contractile force of left atria was 0.85 , 0.68 ,and 0.48 g,respectively (P
