Evaluation of therapeutic efficacy and failure factors of methotrexate in treatment of ectopic pregnancy
- VernacularTitle:甲氨蝶呤治疗异位妊娠疗效及失败因素的评价
- Author:
Qiong LIN
- Publication Type:Journal Article
- Keywords:
methotrexate/TU;
pregnancy;
ectopic/DT;
treatment failure
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the therapeutic efficacy and failure factors in single dose methotrexate intramusculr injection in treatment of ectopic pregnancy. METHODS: The clinical data of 70 successfully treated cases and 10 failed cases were analyzed comparatively,including the duration of menoschesis,serum ?-HCG level,diameter of adnexa mass and abdominal pain before treatment as well as the decline rate of serum ?-HCG level and change of mass diameter after 3 d of treatment. RESULTS: In succeeded group,the average duration of menoschesis,the mean level of serum ?-HCG and average diameter of adnexa mass were 53?5 d ( 14.3 % of patients≥60 d),1483?216 IU?L -1 ( 11.4 % of patients≥4000 IU?L -1 ) and 2.9 ? 0.9 cm( 7.9 % of patients showed increase of mass diameter≥25%),respectively;whereas in failed group,these corresponding figures were 62?6. d( 40.0 %),6661?126 IU?L -1 ( 80.0 %), 4.1 ? 0.6 cm ( 40.0 %),respectively. After 3 d of treatment, 14.3 % of patients in succeeded group revealed a decline rate of serum ?-HCG level≤15%,while 60.0 % of patients in failed group revealed a similar decline rate. CONCLUSION: Methotrexate is an effective drug for treating ectopic pregnancy in its early stage. The serum ?-HCG level before treatment,its decline rate and the change of adnexa mass diameter after 3 d of treatment are closely related to the therapy failure. Presence of fetus heart beating is not a contraindication for drug treatment of ectopic pregnancy.
