The expression of interferon induced protein 10(IP-10) and Th1/Th2 cytokines in the peripheral blood mononuclear cells of ankylosing spondylitis patients
- VernacularTitle:强直性脊柱炎患者外周血单个核细胞干扰素诱导蛋白10及Th1/Th2型细胞因子的表达
- Author:
Jian ZHU
;
Feng HUANG
- Publication Type:Journal Article
- Keywords:
spondylitis, ankylosing;
IFN-?-inducible protein-10;
Th cytokines
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of IP-10 in the pathogenesis of ankylosing spondylitis (AS). Methods The peripheral blood monocytic cells (PBMC) were collected from 39 AS patients, and the mRNA expression of IP-10, IFN-? and IL-4 were measured by semi-quantitive RT-PCR with G3PDH as the internal control. Results The mRNA expression levels of IP-10, IFN-? and IL-4 as well as the rate of IFN-?/IL-4 were elevated in the PBMC of AS patients compared with the healthy controls (P
