Recent development in the study on the transactivation effects of hepatitis virus proteins
- VernacularTitle:肝炎病毒蛋白反式激活作用的研究策略
- Author:
Jun CHENG
- Publication Type:Journal Article
- Keywords:
hepatitis virus;
transactivation;
suppression subtractive hybridization;
cDNA microarray;
signal transduction
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of viral hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is still not clearly elucidated. Cloning of new genes related to the hepatitis virus proteins transactivation by suppression subtractive hybridization (SSH) and cDNA microarray is an important informational resource for the study of the pathogenesis of viral hepatitis. The C-terminally truncated middle surface protein (MHBst) of HBV, HBxAg, HCV core protein, HCV non-structural protein 3 (NS3), and HCV non-structural protein 5A (NS5A) are among the most important transactivating proteins encoded by hepatitis virus genome. The hepatitis virus proteins transactivate gene expression of hepatocytes by disturbing the normal signal transduction, including NF-?B, STAT3, MAPK, Nur77 and PI3K, etc. Therefore, studies in this field would promote a better understanding of the pathogenesis and might help propose potential therapies for liver diseases caused by chronic hepatitis virus infection.
