Application of epidermal growth factor receptor tyrosine kinase inhibitors in cancer therapy
- VernacularTitle:表皮生长因子受体酪氨酸激酶抑制剂在肿瘤治疗中的应用
- Author:
Zhe LI
;
Shoujun YUAN
- Publication Type:Journal Article
- Keywords:
phacology;
epidermal growth factor receptor (EGFR);
tyrosine kinase inhibitors;
cancer therapy;
clinical trial
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Epidermal growth factor receptor (EGFR) tyrosine kinase is over-expressed in numerous human tumors, which plays pivotal roles in cellular signal transduction, and it is involved in a variety of tumor cellular behaviors such as proliferation, metastasis, angiogenesis and so on. Many investigations have indicated that tumor growth can be suppressed by inhibiting EGFR tyrosine kinase activity. Currently, several EGFR tyrosine kinase inhibitors are in clinical trial stage.
