STUDY ON THE ANTITUMOR EFFECT AND IMMUNE MODULATION OF EXTRACT FROM CHLORELLA PYRENOIDOSA CHICK
- VernacularTitle:蛋白核小球藻提取物的抑瘤作用及对免疫功能的影响
- Author:
Ju WANG
;
Hanlin PU
;
An HONG
;
Yun DAI
;
Xiaoke YANG
;
Liumei HE
- Publication Type:Journal Article
- Keywords:
chlorella;
antitumor;
sarcoma 180;
HCA;
immune modulation
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antitumor activity and immune modulation of extract from Chlorella pyrenoidosa Chick. (CE). Methods:Cyclophosphamide is positive control and saline is negative control. S180-bearing and HCA-bearing mice were used as animal model. The changes of the growth of S180 and HCA tumor cells in vitro, the changes of tumor weight in vivo and the effect on immune system such as phagocytosis of macrophages,proliferation of lymphocytes were investigated when CE were used. Results: The tumor cells were killed by CE in vitro. CE inhibited tumor growth markedly in S180 and HCA bearing mice and the effect was enhaced if CE and cyclophosphamide were used simultaneously. CE also enhanced the immune function. Conclusion: CE has the antitumor effect and the effect of immune modulation.
