Computer-assisted three-dimensional reconstruction of microvessel architecture of human anaplastic astrocytoma
- VernacularTitle:计算机辅助的人脑间变性星形细胞瘤微血管构筑三维重建
- Author:
Qingliang WANG
- Publication Type:Journal Article
- Keywords:
glioma;
angiogenesis;
microvascular architecture;
3-D reconstruction
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe three-dimensional(3-D) morphological features of microvessel architecture of human anaplastic astrocytoma.Methods Serial sections of human anaplastic astrocytoma were used to label microvascular endothelial cells with immunohistochemistry using anti-human FⅧ-RAg antibody.The serial images were taken and processed with computer-assisted 3-D reconstruction.Results Partial 3-D structures of the microvessels in anaplastic astrocytoma were successfully reconstructed.The morphology of the vessels was strange in their distribution and branching,which were completely different from normal microvessels of the brain.Some of the tumor vessels showed chaotic structure and some showed tubiform caecum.Conclusion Microvessels in anaplastic astrocytoma appeared multiformity and heterogeneity as well as abundance.3-D reconstruction of such features might be of significance in identifying their architecture,constructing digital tumor microvessel models and targeting the vessels in anti-angiogenesis therapy.
