Protective effects of pioglitazone on heart in ischemia-reperfusion injury rat
- VernacularTitle:吡格列酮对大鼠心脏缺血再灌注损伤的保护作用
- Author:
Zeling CAO
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion;
pioglitazone;
apoptosis;
heart;
PPAR?
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of pioglitazone on the hearts of the rat' s models of ischemia-reperfusion in vivo. METHODS: Sprague-Dawley rats were randomly divided into two groups. One was the group of 30 min reperfusion, which was subdivided into sham (n =5), model (vehicle, n=6) and pioglitazone (3 mg?kg~(-1), n = 7) with 30 min ischemia followed by 30 min reperfusion to detect some data related to cardiac function and the area of myocardium infarction (MI). Another was the group of 2 h reperfusion, which was further subdivided into the sham (n = 5), model(vehicle, n=6), pioglitazone 0.3 mg?kg~(-1) (n = 6), 1 mg?kg~(-1) (n = 1) and 3 mg?kg~(-1) (n = 5) group. Then immunohistochemistry and in situ hybridization were performed to detect the expression of MMP-2 and PPAR? protein and mRNA. RESULTS: Compared with the model group, nec/aar after injecting pioglitazone decreased by 28% (P
