Clinical significance of detecting circulating tumor cells in patients with lung cancer in early stage
- VernacularTitle:早期肺癌外周血中肿瘤细胞的检测及其临床意义探讨
- Author:
Xiaoguang WANG
;
Hong HH
;
Youning LIU
- Publication Type:Journal Article
- Keywords:
immunomagnetic separation;
early stage lung cancer;
circulating tumor cells;
occult micrometastasis;
immunocytochemistry;
reverse transcription-polymerase chain reaction
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the feasibility and clinical significance of detecting circulating tumor cells(CTCs) in peripheral blood of patients with lung cancer in early stage. Methods Three groups of patients (Group A: 15 cases with early stage lung cancer; Group B: 20 cases with benign pulmonary disease; Group C: 20 healthy volunteers) were enrolled for detection of CTCs using immunomagnetic separation(IMS)+ immunocytochemistry(ICC) method and RT-PCR method. The patients in Group A were followed up for 6-9 months. Results By using IMS+ICC it was revealed that in 5 cases of Group A the result was positive, while it was negative in all cases of Group B and Group C. By using RT-PCR method, the result was positive in 7 cases of Group A, 8 cases of Group B and 6 cases of Group C. In the follow-up period, 2 patients of Group A, who were found positive for CTC before and after operation, showed recurrence. Conclusion IMS + ICC method was a sensitive method to detect CTCs in patients with early stage NSCLC. The detection of CTCs in patients with early stage lung cancer might be a relationship with the clinical prognosis of the patient.
