PPARs:Target for lipid metabolism disorder and insulin resistance therapy
- VernacularTitle:PPARs:脂代谢调节与胰岛素增敏治疗药物的作用靶标
- Author:
Cheng XU
;
Lili WANG
;
Yinglin CAO
;
Song LI
- Publication Type:Journal Article
- Keywords:
PPARs;
lipid metabolism;
insulin resistance
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The peroxisome prolifrator-activated receptors(PPARs)? and ? constitute a subfamily of nuclear receptors. PPAR? has been shown to be activat ed by the hypolipidemic drugs of the fibrate class; While the antidiabetic TZD a re synthetic ligands for PPAR?. Upon binding and activation by their ligands, t hey regulate the transcription of numerous genes involving lipid metabolism and insulin resistance. The research indicated that PPAR? also plays a key role in lipid metabolism. PPARs therefore constitute interesting targets for the develop ment of single and dual agonists useful in the treatment of obesity and type 2 d iabetes.