Lipoprotein lipase Activatoor NO-1886
- VernacularTitle:脂蛋白酯酶活化剂NO-1886的研究进展
- Author:
Manbo CAI
;
Weidong YIN
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
cardiovascular disease;
lipids;
lipoprot ein lipase
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
NO-1886 increases LPL mRNA and LPL activity in adipose tiss ue, myocardium and skeletal muscle, resulting in an elevation of postheparin pl asma LPL activity and LPL mass in rats. NO-1886 also decreasess plasma TG con centration and causes a concomitant rise in plasma HDL-C, reduces plasma gluco se, improves insulin resistance and ?-cell dysfunction. Therefore, the LPL act ivator NO-1886 or other possible LPL activating agents are potentially benefici al for the treatment of hypertriglyceridemia, hypo-HDL cholesterolemia, and pro tection from atheroscleroosis and diabetes.
