Molecular mechanisms for the novel compound PPVP against atherosclerosis in rat fed with hypercholesterol diet
- VernacularTitle:新化合物PPVP在大鼠动脉粥样硬化模型上抗动脉粥样硬化分子机制的研究
- Author:
Limei SHAN
;
Yanling ZHAO
;
Jinchao ZHANG
;
Wenyu CUI
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
PPVP;
nitric oxide;
IL-8
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the anti-atherosclerosis mechanisms of the novel compound PPVP. METHODSThirty-six male rats were a ssigned to control, model and PPVP 5 mg?kg -1 groups randomly. The rats in model and PPVP 5 mg?kg -1 groups were fed with hypercholesterol diet for inducing atherolcerosis model. The following variables were measured: HE stainin g of rat aorta; serum level of TC, LDL-CHO, HDL-CHO, IL-8, ET-1, PGI 2, TXA 2 and NO. RESULTSPPVP increased serum level of NO, decreased plasma level of TXA 2 and inhibited the over expression of IL-8. CONC LUSIONThe anti-atherogenic effect of PPVP seems to be closely involved in increasing serum NO level, decreasing plasma level of TXA 2, and inhibiting over expression of IL-8. The result also suggests that the anti-atherogenic ef fect of PPVP in high cholesterol-fed rat may not due to the regulation of plasm a lipid profile, plasma level of ET-1 and PGI 2.
